Publications
Recent Publications
E. Martinez-Terroba, LM. Plasek-Hegde, I. Chiotakakos, V. Li, FJ. de Miguel, C. Robles-Oteiza, A. Tyagi, K. Politi, JR. Zamudio, and N. Dimitrova (2024). Overexpressed Malat1 drives metastasis through inflammatory reprogramming of lung adenocarcinoma microenvironment. Science Immunology, in print.
J. Ferrer and N. Dimitrova (2024). Transcription regulation by long non-coding RNAs: mechanisms and disease relevance. Nature Reviews Molecular Cell Biology. 25(5):396-415.
L. Winkler, M. Jimenez, JT. Zimmer, A. Williams, MD Simon, and N. Dimitrova (2022). Functional elements of the cis regulatory lincRNA-p21. Cell Reports, 39, 110687.
L. Winkler and N. Dimitrova (2021). A mechanistic view of long noncoding RNAs in cancer. WIREs RNA. Oct 19:e1699. doi: 10.1002/wrna.1699.
E. Tesfaye, E. Martinez-Terroba, J. Bendor, L. Winkler, K. Chen, DM. Feldser, JR. Zamudio, and N. Dimitrova (2021). The p53 transcriptional response across tumor types reveals core and senescence-specific signatures modulated by long noncoding RNAs. PNAS, 118(31): e2025539118.
FJ. Sanchez-Rivera, J. Ryan, YM. Soto-Feliciano, M. Clare Beytagh, L. Xuan, DM. Feldser, MT. Hemann, J. Zamudio, N. Dimitrova, A. Letai, and T. Jacks (2021) Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. PNAS 111(23): e2019740118.
C. Olivero and N. Dimitrova (2020). Identification and characterization of functional long noncoding RNAs in cancer. The FASEB J. 34(12):15630-15646.
E. Martínez-Terroba and N. Dimitrova (2020). Long noncoding RNA amplified in lung cancer rewires cancer pathways. Journal of Cell Biology, 219(9): e202007098.
C. Olivero, E. Martínez-Terroba, J. Zimmer, C. Liao, E. Tesfaye, N. Hooshdaran, J. Bendor, D. Fang, J. Schofield, M. Simon, J. Zamudio and N. Dimitrova (2020) p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis. Molecular Cell, 77(4):761-774.
N. Dimitrova (2018). Genetic variations of lncRNAs in cancer. Chakrabvarti and Mirta. Translational Epigenetics Series: Cancer and Noncoding RNAs. Eslevier.
2016-2010
N. Dimitrova, V. Gocheva, A. Bhutkar, R. Resnick, RM. Jong, KM. Miller, J. Bendor, and T. Jacks (2016). Stromal expression of miR-143/145 promotes neoangiogenesis in lung cancer development. Cancer Discov. 6(2): 188-201. [Full text]
F. Lottersberger, RA. Karssemeijer, N. Dimitrova, and T. de Lange (2015). 53BP1 and the LINC complex promote microtubule-dependent DSB mobility and DNA repair. Cell 163: 880-893. [Full text]
N. Dimitrova, JR. Zamudio, RM. Jong, D. Soukup, R. Resnick, K. Sarma, AJ. Ward, A. Raj, JT. Lee, PA. Sharp, and T. Jacks (2014). LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint. Molecular Cell 54: 777-790. [Full text]
MS. Kumar, A. Narla, A. Nonami, N. Dimitrova, B. Ball, JR. McAuley, C. Chin, C. Chen, J. Kutok, N. Galili, A. Raza, E. Attar, DG. Gilliland, T. Jacks, and BL. Ebert (2011). Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q- syndrome. Blood 118 (17): 4666-73. [PDF]
2009-2006
N. Dimitrova and T. de Lange (2009). Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2. Molecular and Cellular Biology 20: 5552-63. [PDF]
N. Dimitrova (2009). Telomere binding proteins in human cells. Cancer Drug Discovery & Development: Telomeres and Telomerase in Cancer. Humana Press Inc.
N. Dimitrova, YC. Chen, D. Spector, and T. de Lange (2008). 53BP1 promotes non-homologous end-joining of telomeres by increasing chromatin mobility. Nature 456 (7221): 524-8. [PDF]
N. Dimitrova and T. de Lange (2006). MDC1 accelerates non-homologous end-joining of dysfunctional telomeres. Genes and Development 20: 3238-3243. [Full text]