Recent Publications

J. Ferrer and N. Dimitrova (2024). Transcription regulation by long non-coding RNAs: mechanisms and disease relevance. Nature Reviews Molecular Cell Biology

E. Martinez-Terroba, FJ. de Miguel, V. Li, C. Robles-Oteiza, K. Politi, JR. Zamudio, and N. Dimitrova (2023). Overexpressed Malat1 drives metastasis through inflammatory reprogramming of lung adenocarcinoma microenvironment. Biorxiv

L. Winkler, M. Jimenez, JT. Zimmer, A. Williams, MD Simon, and N. Dimitrova (2022). Functional elements of the cis regulatory lincRNA-p21. Cell Reports, 39, 110687. 

L. Winkler and N. Dimitrova (2021). A mechanistic view of long noncoding RNAs in cancer. WIREs RNA. Oct 19:e1699. doi: 10.1002/wrna.1699. 

E. Tesfaye, E. Martinez-Terroba, J. Bendor, L. Winkler, K. Chen, DM. Feldser, JR. Zamudio, and N. Dimitrova (2021). The p53 transcriptional response across tumor types reveals core and senescence-specific signatures modulated by long noncoding RNAs. PNAS, 118(31): e2025539118.

FJ. Sanchez-Rivera, J. Ryan, YM. Soto-Feliciano, M. Clare Beytagh, L. Xuan, DM. Feldser, MT. Hemann, J. Zamudio, N. Dimitrova, A. Letai, and T. Jacks (2021) Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. PNAS 111(23): e2019740118.

C. Olivero and N. Dimitrova (2020). Identification and characterization of functional long noncoding RNAs in cancer. The FASEB J. 34(12):15630-15646.

E. Martínez-Terroba and N. Dimitrova (2020). Long noncoding RNA amplified in lung cancer rewires cancer pathways. Journal of Cell Biology, 219(9): e202007098. 

C. Olivero, E. Martínez-Terroba, J. Zimmer, C. Liao, E. Tesfaye, N. Hooshdaran, J. Bendor, D. Fang, J. Schofield, M. Simon, J. Zamudio and N. Dimitrova (2020) p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress TumorigenesisMolecular Cell, 77(4):761-774. 

N. Dimitrova (2018). Genetic variations of lncRNAs in cancer. Chakrabvarti and Mirta. Translational Epigenetics Series: Cancer and Noncoding RNAs. Eslevier. 


N. Dimitrova, V. Gocheva, A. Bhutkar, R. Resnick, RM. Jong, KM. Miller, J. Bendor, and T. Jacks (2016).  Stromal expression of miR-143/145 promotes neoangiogenesis in lung cancer development. Cancer Discov. 6(2): 188-201. [Full text]

F. Lottersberger, RA. Karssemeijer, N. Dimitrova, and T. de Lange (2015).  53BP1 and the LINC complex promote microtubule-dependent DSB mobility and DNA repair. Cell 163: 880-893. [Full text]

N. Dimitrova, JR. Zamudio, RM. Jong, D. Soukup, R. Resnick, K. Sarma, AJ. Ward, A. Raj, JT. Lee, PA. Sharp, and T. Jacks (2014). LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint. Molecular Cell 54: 777-790. [Full text]

MS. Kumar, A. Narla, A. Nonami, N. Dimitrova, B. Ball, JR. McAuley, C. Chin, C. Chen, J. Kutok, N. Galili, A. Raza, E. Attar, DG. Gilliland, T. Jacks, and BL. Ebert (2011). Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q- syndrome. Blood 118 (17): 4666-73. [PDF]


N. Dimitrova and T. de Lange (2009). Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2. Molecular and Cellular Biology 20: 5552-63. [PDF]

N. Dimitrova (2009). Telomere binding proteins in human cells. Cancer Drug Discovery & Development: Telomeres and Telomerase in Cancer. Humana Press Inc.

N. Dimitrova, YC. Chen, D. Spector, and T. de Lange (2008). 53BP1 promotes non-homologous end-joining of telomeres by increasing chromatin mobility. Nature 456 (7221): 524-8. [PDF]

N. Dimitrova and T. de Lange (2006). MDC1 accelerates non-homologous end-joining of dysfunctional telomeres. Genes and Development 20: 3238-3243. [Full text]